Despite having slightly larger lesion sizes and bacterial burden during infection (Fig 2A and 2B), CGD mice did not have significant differences in their mRNA levels for IL-1ß, IL-6, or IL-17A (Fig 2D), consistent with their immunodeficiency reflecting a defect in neutrophil function rather than cytokine production [25,26]. The gene discussed is IL17A; the disease is immune system disorder.