Danda et al. demonstrated that plasmid carrying the suicide gene was selectively expressed in the cancer cells (retinoblastoma) overexpressing Epithelial cell adhesion molecule (EpCAM) [51], and Dancer et al. demonstrated in vivo reduction of tumor volume and the number of blood vessels in the study targeting a suicide gene in the endothelium of transgenic mice [52]. Here, EPCAM is linked to neoplasm.