Prognostic factors in DLBCL may be related to the patient (e.g. age and performance status), to the tumor itself and the aggressiveness of its markers (e.g. stage, tumor burden, proliferation index, LDH or beta-2-microglobulin) and to the therapeutic strategy (e.g. therapeutic regimen or relative dose intensity (RDI)). The gene discussed is B2M; the disease is neoplasm.