MiR-17 and miR-20a may block the G1/S transition by repressing Rb-E2F signaling by directly targeting E2F1 molecules in normal diploid human cells [44], and miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells [45]. The gene discussed is RB1; the disease is malignant colon neoplasm.