For example, oncogenes: CDK6 and MDM2, tumor suppressor gene: CHEK2, oxidative stress genes: SOD1 (encoding a member of the p53 family of transcription factors) and TP63, and IGF signaling genes: IGF1, IGFBP5 and IGFBP7. Since the incidence of ependymomas from the spine increases with age, it is likely that the senescence pathway is involved in its development. The gene discussed is MDM2; the disease is ependymoma.