TP53 and ependymoma: For example, oncogenes: CDK6 and MDM2, tumor suppressor gene: CHEK2, oxidative stress genes: SOD1 (encoding a member of the p53 family of transcription factors) and TP63, and IGF signaling genes: IGF1, IGFBP5 and IGFBP7. Since the incidence of ependymomas from the spine increases with age, it is likely that the senescence pathway is involved in its development.