KDM5B and hepatocellular carcinoma: 1C). The protein level of JARID1B in these tissue samples were also analyzed by western blot (Figure 1B). The protein level of JARID1B was upregulated in HCCs samples as compared with the normal adjacent tissues samples. Furthermore, we found that JARID1B protein expression was also significantly correlated with distant metastasis in HCC tissues (Figure. 1D). As showed in Supplemental Figure 1A and 1B, expression level of JARID1B protein and mRNA in mesenchymal HCC cell lines was higher than that in the epithelia HCC cell lines.