Misregulation of the NRMT1 substrate CENP-A, a prognostic marker for relapse in ER+ breast cancer [51], also leads to multipolar spindle formation [52], and we predict its impaired DNA binding ability after loss of N-terminal methylation [53] may also contribute to the phenotypes seen with NRMT1 loss. Here, NTMT1 is linked to breast carcinoma.