AKT1 and diffuse large B-cell lymphoma: Consistently, a functional inhibitor of PI3K, LY294002, up-regulated the expression of FOXO1 and Bim in DLBCL cells (Fig. 3C), which further suggested that the FOXO1/Bim axis may be an important target regulated by the PI3K/AKT signaling in DLBCL.