EPCAM and neoplasm: Obtained CTCs, free from hypotonic damage [26] and anti-EpCAM purturbing, are suitable for primary tumor cell culture and a series of subsequent studies including gene mutation analysis performed on the individual CTC [27] as well as establishing tumorigenic CTC- or CTC subtype-derived xenograft mouse models (CDXs) which could mirror the donor patient's response to chemotherapy [28].