High USP22 expression was mainly found in patients with more advanced tumor stages (50/74 in stages III+IV vs. 8/30 in stages I+II, p = 0.000) and high-grade tumors (23/24 in grades 3-4 vs. 35/80 in grades 1-2, p = 0.000). The gene discussed is USP22; the disease is neoplasm.