Confirming these studies, we found BRAF and NRAS mutations as almost mutually exclusive genetic events and enrichment of NF1 and KIT alterations in melanomas wild-type for BRAF and NRAS. Furthermore, we found alterations in CDKN2A, CDK4, CCND1 and RB1 to be almost mutually exclusive genetic events. The gene discussed is CDK4; the disease is melanoma.