Next, we focused on a set of genes highly implicated in melanomagenesis, including BRAF, NRAS, KIT, CDK4, CDKN2A, TP53, PTEN, CTNNB1, NF1, RB1 and PIK3CA. To provide a more comprehensive context of the mutational landscape we also included focal amplifications and homozygous deletions of melanoma signature genes, like MITF, KIT, CDK4, NOTCH2 and CCND1, CDKN2A and PTEN (Figure 2A). This evidence concerns the gene RB1 and melanoma.