MITF and melanoma: Analysis of the mutation spectrum within the context of the gene expression phenotypes showed that: i) CDKN2A alterations were more prevalent in the proliferative-classified melanomas (P=0.05, Fisher's exact test, consistent with previous reports [9]), ii) pigmentation-classified melanomas were enriched for genetic events in CTNNB1, MITF or CCND1 (P=0.02, P=0.04 and P=0.04, respectively, Fisher's exact test), whereas iii) BRAF and NRAS mutations were equally distributed across phenotypes (Supplementary Table 2).