Here, for the first time, we described cellular apoptosis induced by infection of MV-Edm was mainly mediated by caspase 3 and elucidated the role of the caspase 3 mediated apoptosis in the process of oncolytic virotherapy with MV-Edm, besides confirming the potent antitumor activity of MV-Edm against human CC cells in vitro and in vivo. Here, CASP3 is linked to infection.