Microarray analysis revealed that the mRNA level of CCNB1 was not altered following SYK023 treatment; however, CCNB1 interacting protein 1 (CCNB1IP1), an E3 ubiquitin ligase targeting cyclin B1 [40], was increased (data not shown), suggesting that SYK023 may affect more anti-tumor pathways than BA to inhibit cancer cell proliferation. This evidence concerns the gene CCNB1 and neoplasm.