Microarray analysis revealed that the mRNA level of CCNB1 was not altered following SYK023 treatment; however, CCNB1 interacting protein 1 (CCNB1IP1), an E3 ubiquitin ligase targeting cyclin B1 [40], was increased (data not shown), suggesting that SYK023 may affect more anti-tumor pathways than BA to inhibit cancer cell proliferation. The gene discussed is CCNB1IP1; the disease is cancer.