EMT, with downregulation of E-cadherin expression as a hallmark [35], is regarded as a prerequisite for the initiating steps of the metastatic cascade involving detachment of the cells from the primary tumor, intravasation, survival in the circulation, extravasation and early colonization by the establishment of the dormant micrometastases in the microenvironment of the distant organ. This evidence concerns the gene CDH1 and neoplasm.