TNFRSF1B and colonic neoplasm: Immunohistochemical staining of colon tumor tissues showed upregulation of TNFR1 expression in IL-32α Tg mice compared to the tumor tissues in non-Tg mice, while there was no difference of the expression of TNFR2 between non-Tg mice and IL-32α Tg mice (Figure 2A).