Based on these data, we found that 54 of the 82 proteins further differentiated PD from ALS-derived microvesicles (Fig.2B, and Tables S3, S4) with 23 of these 54 proteins previously shown to be constituents of exosomes (ExoCarta dataset).14 Notably, we did not detect enrichment for disease-associated proteins such as α-synuclein or tau in these preparations. This evidence concerns the gene MAPT and amyotrophic lateral sclerosis.