The association of SNP +45 T > G in the adiponectin gene with T2D and insulin resistance has extensively been investigated in several populations including the Iranian ones There is no consistency among these studies; however, more studies have indicated that SNP +45 T > G in the adiponectin gene is associated with insulin resistance and T2D [20].The association of adiponectin gene polymorphisms and GDM has been evaluated in recent studies [22-24] and controversial results have been obtained. This evidence concerns the gene ADIPOQ and Insulin resistance.