For example, miRNA profiling studies showed that distinct patterns of miRNA characterize different hematopoietic differentiation stages in acute leukemia samples: the BCR-ABL, TEL-AML1 -(acute myeloid leukemia 1 also known as runt-related transcription factor 1 (RUNX1)) and mixed lineage leukemia (MLL) rearrangements could be distinguished [109,110]. The gene discussed is RUNX1; the disease is acute leukemia.