Cases of thyroid dysgenesis are usually sporadic, inherited genetic defects are only recognized in about 2% of all cases and result from transcription factor genes mutations (PAX8, NKX2-1/TITF1, NXK2-5, FOXE1/TITF-2) [9]. Here, NKX2-1 is linked to hypothyroidism, congenital, nongoitrous, 2.