AIDS-RL with >300 CD4+ lymphocytes/mm3 had lower expression of NKG2D than HIV-negative lymphoma patients (M = 23.65 IQR[15.45-28.19] vs 31.89[25.71-42.17], p = 0.03), than HS (M = 31.78 IQR[27.40-37.50], p = 0.005) or HIV + patients without lymphoma but >300 CD4+ lymphocytes/mm3 (M = 24.92 IQR[18.68-35.45], p = 0.005). This evidence concerns the gene KLRK1 and lymphoma.