2B4/CD244/P38 expression was lower in AIDS-RL with <300 CD4+ lymphocytes/mm3 than in HIV-negative lymphoma patients (M = 37.36 IQR[21.45-51.68] vs 63.43[45.16-86.86], p = 0.002) and than in HS (M = 51.64[38.93-78.76], p = 0.023). The gene discussed is CD4; the disease is lymphoma.