binclude 1) abnormal or non-reassuring foetal surveillance tests 2) abnormal Doppler flow velocimetry waveform analysis suggestive of foetal hypoxaemia 3) oligohydramnios 4) post natal birth weight less than 10th percentile for gestational age investigators should classify APS patients in I) more than one laboratory criteria present or IIa) ACA present alone or IIb) LA present alone or IIc) anti-beta2GP-I ab present aloned if less than 12 weeks or more than 5 years have gone by since clinical manifestation and confirmation of aPL positivity, then APS should not be defined. The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.