These include Tgfb3, which is important in Th17-mediated autoimmunity (Lee et al., 2012), Igf1r, which is highly expressed in T-ALL cells (Medyouf et al., 2011), Rsad2 (viperin), which is a regulator of viral infection (Seo et al., 2011), Cd24a, which is important in T-cell homeostasis (Li et al., 2004) and Dusp16, which is a negative regulator of JNK in T-cells (Kumabe et al., 2010). The gene discussed is IGF1R; the disease is acute lymphoblastic leukemia.