Of interest are also gene changes that have been observed in other ataxic mouse models such as the downregulation of the Car2 gene (Supplementary Material, Fig. S2), encoding carbonic anhydrase II, which has also been reported in a mouse model of spinocerebellar ataxia type 7 (SCA7) (49). The gene discussed is CA2; the disease is spinocerebellar ataxia 7.