Intriguingly, separate downregulation of GDF15, MYC and SERPINA3 by using a small interfering RNA (siRNA) approach did not reverse the #hMADS-CM-induced inhibition of ADCC (Additional file 10: Figure S7), suggesting that the phenotypic alterations of tumor cells induced by exposure to adipocyte-conditioned medium are likely to be complex. The gene discussed is GDF15; the disease is neoplasm.