Tissue p-STAT3 presented a predominant immunostain rate (≧10% immunostaining of hepatocytes) as compared to that of p-STAT1 in all liver (51/86 versus 25/86, P < 0.001) and CH (32/52 versus 19/52, P = 0.003) and HCC specimens (19/34 versus 6/34, P = 0.024) (Figures 4A, B). Here, STAT3 is linked to hepatocellular carcinoma.