TNF and liver cancer: Indeed, our study only found expressions of serum IL-6, IL-27, and TNF-α rather than VEGF obvious in CH-total rather than HG groups (Figure 1), which concurred with previous study: IL-6, IL-27, or TNF-α playing an inflammatory role in regulating hepatocyte proliferation and regeneration, and VEGF playing a major role in pathogenesis of liver cancer [17,18,20,22,23,26,28].