While correlating among IL-6, IL-27, TNF-α, and VEGF with Child-Pugh Classification and 6-month mortality with presence or not of cirrhosis, only IL-6 over-expression strongly correlated with preservation of liver function and 6-month mortality in HCC-total (r = 0.365; P = 0.002, r = 0.488; P < 0.001 respectively) or cirrhotic HCC (r = 0.376; P = 0.002, r = 0.577; P < 0.001 respectively). Here, IL6 is linked to Cirrhosis.