In contrast to multifunctional activities of IL-6 and IL-27 and TNF-α in different stages of liver disease, vascular endothelial growth factor (VEGF), an essential regulator during angiogenesis rather than inflammatory process [15,25], triggers blood vessel growth for nutrition of cancer cells and affects survival in advanced HCC cases [26-28] . Here, IL27 is linked to hepatocellular carcinoma.