TP53 and neoplasm: To better relate Notch to other gene categories, we compared mutation frequencies for Notch components to the set of oncogenes and tumor suppressor genes used in Figure 1A-B (p53, H/K/N Ras, APC, Patched1-2 and ErbB1-4) as well as to a set of house-keeping genes that have not been reported to be involved in tumor formation: polyadenylate-binding nuclear protein1 (PABPN1), fucose-1-phosphate guanylyltransferase (FPGT) and Non-POU domain-containing octamer-binding protein (NONO) [39].