Third, the MIRC1 (miR-17-92) microRNA cluster, which can activate AKT in a variety of contexts, is amplified and linked to cell death suppression in human retinoblastoma, and its overexpression in retinal cells with Rb1 and p107 deletion promotes rapid retinoblastoma [22-24]. The gene discussed is AKT1; the disease is retinoblastoma.