In the absence of Wnt, β-catenin is phosphorylated by glycogen synthase kinase 3 (GSK3) within the Axin destruction complex (‘Axin degradasome'2) that also contains the Adenomatous Polyposis Coli tumour suppressor, which earmarks β-catenin for ubiquitination and subsequent proteasomal degradation3. This evidence concerns the gene AXIN1 and neoplasm.