These 33 enzymes represent >1/3 of all known human DUBs, and they include members of all four major DUB families—20 USPs (including CYLD, USP14 an USP8), 8 Ovarian Tumour (OTU) deubiquitinases (including Trabid and Cezanne), 3 ubiquitin C-terminal hydrolases (UCHs) and 2 JAMM metalloproteases. Here, USP8 is linked to ovarian neoplasm.