Human patients with mutations in both SLC26A3 alleles present with infertility that is associated with absence of SLC26A3 (Cl−-losing diarrhea, CLD) expression in the efferent ducts, oligoasthenoteratozoospermia, high Cl− concentration and low pH in seminal plasma, and spermatoceles (Hihnala et al. The gene discussed is SLC26A3; the disease is spermatocele.