All these results imply that in rPCIS and mPCIS there was a spontaneous induction of early fibrogenesis, which can be measured by gene expression of Hsp47 and Fn2. Our result of the early-onset of fibrosis in PCIS are in line with the results in a liver fibrosis model using precision-cut liver slices, which we already successfully used in studying antifibrotic compounds (Westra et al. Here, SERPINH1 is linked to Hepatic fibrosis.