Also, increasing disseminated intravascular coagulation (DIC) score was associated with increased syndecan-1 (P <0.001) and thrombomodulin (P <0.001) and reduced protein C (P <0.001), whereas tPA and PAI-1 remained stable across DIC scores (data not shown). The gene discussed is SDC1; the disease is Disseminated intravascular coagulation.