CACNA1H and epilepsy: While some prior studies have suggested a role of rare gain of function mutations in CACNA1H in epilepsy (Chen et al., 2003; Liang et al., 2006; Heron et al., 2007), these studies have not approached genome-wide levels of significance, do not appear to confer high risk, and have not been uniformly replicated (Heron et al., 2004; Chioza et al., 2006; Liang et al., 2006).