Increased expression of cyclin D1 and amplification of its gene along with immunolabelling of HBME-1 in WDT-UMP areas showing cytological features of papillary thyroid carcinoma within follicular adenomatoid nodules suggest that these areas could correspond to a precursor lesion of follicular variant of papillary thyroid carcinoma. The gene discussed is CCND1; the disease is differentiated thyroid carcinoma.