Our experimental results showed that global cerebral ischemia-reperfusion reduced the activity of SOD (an eliminator of free radicals), increased the content of MDA(an indicator of lipid peroxidation) and NF-κBp65 (an important transcription factor that plays a pivotal role in mediating inflammatory response to pro-inflammatory cytokines and ROS) protein expression. This evidence concerns the gene SOD1 and Cerebral ischemia.