Quantification of DclK1-positive cells in pancreatic tumor from control diet-fed mice showed 80 ± 1.34 (mean ± SEM), as compared with 45 ± 1.54 and 30 ± 1.25 in tissue from mice treated with low or high dose licofelone, for a decrease in cancer stem cells by 43% and 62% (P > 0.0001), respectively (Supplementary Fig. 3B–3C). Here, DCLK1 is linked to pancreatic neoplasm.