Indeed, although the intensity of IGF-1R immunostaining has generally been reported to increase from benign prostatic hyperplasia (BPH) to PIN to carcinoma [16], several studies have not confirmed this linear relationship and have reported that reduced IGF-1R is associated with hyperplasia and proliferation or metastatic lesions [17, 18]. The gene discussed is IGF1R; the disease is prostate intraepithelial neoplasia.