HLTF and adenocarcinoma: Consistent with the findings that ubiquitylation of HLTF causes its degradation, Qing et al. determined that in A549 adenocarcinoma human alveolar basal epithelial cells the deubiquitylating enzyme USP7 binds and deubiquitylates HLTF after DNA damage or replication stress induced by etoposide, HU, or MMS, resulting in HLTF stabilization [83].