RAD51 then exchanges with RPA to form RAD51-ssDNA nucleoprotein filaments, which inhibit DNA resection by Mre11.14 Depleting RAD51 increases accumulation of ssDNA lesions.14 Owing to the high sequence homology shared by RAD51 and DMC1, it is plausible that both proteins maintain overlapping functions in mitotic tumor cells. This evidence concerns the gene RPA1 and neoplasm.