NFKB1 and Duchenne muscular dystrophy: The transcription factor nuclear factor-κB (NF-κB) is highly activated in the skeletal muscle (henceforth simply termed ‘muscle') of patients suffering from Duchenne muscular dystrophy (DMD).1 In this fatal neuromuscular disease, absence of the cytoskeletal protein dystrophin results in muscle membrane instability, ongoing muscle degeneration and chronic inflammation.