The prevalence of diabetic kidney disease in the United States did not markedly decreased among diabetes population between 1988 and 2008, despite the widespread use of glucose-lowering and renoprotective drugs (eg, renin–angiotensin–aldosterone system blockers).8 This phenomenon may be explained by the hypothesis that the harmful effects of hypoglycemia during the treatment of DM may affect kidney function. The gene discussed is REN; the disease is diabetes mellitus.