MMP9 and acute myeloid leukemia: However, leukemic blast cells produce MMP2 that may serve as a marker for dissemination in myeloproliferative malignancies.51 Recently, leukemic blast cells purified from the peripheral blood of patients with Acute myeloid leukemia have been demonstrated to regularly release MMP2 and MMP9.52 Some studies show the involvement of MMPs and TIMPs in growth and progression of lymphoid neoplasias.53–55