MMP2 −735 C > T polymorphism affects MMP2 expression or activity and have been associated with cardiovascular diseases16,25,26 and obesity.27,28 In another study, it was shown that blood pressure is associated with circulating MMP2 concentrations, and that the CT genotype and the T allele for the C −735T polymorphism are less common in obesity. The gene discussed is MMP2; the disease is obesity due to melanocortin 4 receptor deficiency.