In addition, KCNJ5 and CYP11B2 genes are more highly expressed in the APAs with KCNJ5 mutations than wild-type KCNJ5.5,6,14 Female patients have a significantly higher KCNJ5 mutation rate than male patients, which was confirmed by several studies.4,6–9,14 Patients with KCNJ5 mutation are significantly younger at diagnosis than those without KCNJ5 mutation.4,7,8 Furthermore, the KCNJ5 mutation carriers present with increased aldosterone and reduced potassium levels as previously reported.5,8 The adenoma size is also larger3,4,9 in the KCNJ5 mutation carriers. The gene discussed is KCNJ5; the disease is adenoma.