Compared with participants with normal pregnancy, first trimester serum sFLT1 and ADMA levels of participants who developed preeclampsia were significantly higher (sFLT1: 0.321±0.023 vs. 0.308±0.019 ng/ml, P = 0.001; ADMA: 0.86±0.16 vs. 0.68±0.20 μM, P<0.001) (Table 1), and serum PGF levels were significantly lower (115.72±32.55 vs. 217.30±74.48 pg/ml, P<0.001) (Table 1). This evidence concerns the gene PGF and preeclampsia.