Furthermore, diabetes up-regulated the genes of phase I and II detoxification enzymes such as, CYP2J4, CYP1A1, P450 (cytochrome) oxidoreductase, Nat8, GCNT2, GSTYc2. Such significant increases in these genes indicate the rise of diabetic detoxification processes which is also confirmed by pathway analysis. The gene discussed is POR; the disease is diabetes mellitus.