The expression levels of genes exhibiting the greatest increase in D+RSV group were Lcn2, Abcc3, GPx2, CYP1A1, CYP26A1, Igfbp2, GST-A5 and Lgals3. It is clear that an increase in the expression of these genes might be an indicator of the enhanced protection mechanisms for metabolic changes occurred as a result of diabetes, since most of these genes are functioning in detoxification metabolism. The gene discussed is CYP26A1; the disease is diabetes mellitus.