CYP1A1 and diabetes mellitus: Furthermore, diabetes up-regulated the genes of phase I and II detoxification enzymes such as, CYP2J4, CYP1A1, P450 (cytochrome) oxidoreductase, Nat8, GCNT2, GSTYc2. Such significant increases in these genes indicate the rise of diabetic detoxification processes which is also confirmed by pathway analysis.