CFH and age-related macular degeneration: This report provides long-term population-based observations regarding the relationships of age, sex, and presence of risk alleles for two AMD candidate genes, CFH Y402H rs1061170 and ARMS2 A69S rs10490924, to the incidence of small hard drusen, as well as their role in the natural history of AMD in its earliest clinical stages using grading of stereoscopic 30° color fundus film photography.