Additionally, under Se-exposure and S-deficiency, S. pinnata hyperaccumulates and tolerates Se due to its ability to convert SeO2-4 to non-toxic organic-seleno-compounds by down-regulating APS1, APS2, and APS4. However, under S-sufficient and Se-exposure, adoption of different types of regulatory mechanisms and subcellular-localization were revealed in S. pinnata and Brassica juncea, where Se up-regulated APS1 and APS4 but was not able to affect APS2 in S. pinnata (Schiavon et al., 2015). The gene discussed is NUDT10; the disease is hyperinsulinemic hypoglycemia, familial, 4.