IL17A and rheumatoid arthritis: IL-17A alone had no significant effect on Wnt5a expression, while TNF-α alone or in combination with IL-17A induced a significant increase after 12 h in both OA and RA FLS (1.6-fold increase with IL-17A + TNF-α vs. 0.9-fold without cytokines in OA FLS, **p < 0.005; 1.4-fold increase with IL-17A + TNF-α vs. 0.9-fold without cytokines in RA FLS, *p < 0.05) (Figure 3B).