TNF and rheumatoid arthritis: Cytokine treatment decreased Runx2 expression in OA and RA FLS at early time points (0.6-fold with IL-17A + TNF-α vs. 1-fold without cytokines in OA FLS and 0.5-fold with IL-17A + TNF-α vs. 1-fold without cytokines in RA FLS at 6 h, **p < 0.005), whereas, at later time points, these cytokines had no effect on Runx2 expression.