Therefore, we tested the effects of ICA-105665, a novel small molecule that selectively opens KCNQ2/3 and KCNQ3/5 channels (Kv7.2/7.3 and Kv7.3/7.5) (25, 26) to determine its effects on salicylate-induced hearing loss. This evidence concerns the gene KCNQ3 and hearing loss disorder.