Antioxidants such as quercetin (Tang et al., 2009), edaravone (Kato et al., 2009), epigallocatechin gallate (Li et al., 2007), and resveratrol (Xu et al., 2014b) significantly inhibit HMGB1 release in animal models of sepsis, suggesting that oxidative stress mediates HMGB1 secretion during infection. The gene discussed is HMGB1; the disease is Sepsis.