AQP4 modulation by metabotropic receptors or signaling chain stimuli, particularly inhibition of AQP4 up-regulation, offers a possible therapeutic avenue to minimize brain edema from the excessive glutamate that is released during ischemia (Gunnarson et al., 2008; Pa Santes-Morales and Cruz-Rangel, 2010). This evidence concerns the gene AQP4 and ischemia.